Gram-negative bloodstream infection reduction plan and tools


A collection of tools to help you reduce gram negative blood stream infections (GNBSIs)

The NHS Long Term Plan supports a 50% reduction in Gram-negative bloodstream infections (GNBSIs) by 2024/25.

To help NHS systems achieve this, NHS England and NHS Improvement has developed the GNBSI reduction toolkit: a collection of guidance notes, actions and resources you can use to shape your approach to reducing GNBSI.

This toolkit is outlined across six areas, with a seventh laying out further next steps to follow. Click on the links below for more information:

Governance and leadership

Guidance on devising system structures and processes to allow integrated systems to tackle GNBSI - including examples of good practice.
Governance resources


Collecting and analysing data, and promoting system management.
Surveillance resources

Antiobiotic/antimicrobial stewardship

Developing antimicrobial stewardship across integrated systems and working beyond individual organisations.
Stewardship resources

Urinary tract infection (UTI) and catheter-associated urinary tract infection (CAUTI)

Actions concerned specifically with reducing UTI and CAUTI - leading causes of GNBSI and E. coli.
UTI/CAUTI resources


Improving patient and population hydration, as a means of reducing infection.
Hydration resources

Education and awareness

Recommended actions and examples of education work in systems across England.
Education resources

Next steps

Further actions to consider once the above processes have been undertaken.
Next steps

Additional resources:

GNBSI toolkit planner XLSX, 35.4 KB

Planning document allowing responsibilities and timescales to be allocated to all actions across the toolkit areas

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