Systematic reviews and meta-analysis focused on Gram-negative bloodstream infections (GNBSI) and interventions specifically aimed at carbapenemase-producing Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosa.
With the overwhelming amount of evidence and studies being published it is almost impossible for clinicians to keep up-to-date with all the literature. Systematic reviews provide summaries of outcomes and interventions, whether they are successful or not, in one publication.
Systematic reviews or meta-analysis for reducing GNBSI
Healthcare‐associated infections due to multidrug‐resistant (MDR) Gram‐negative bacteria (MDR‐GNB) are a leading cause of morbidity and mortality worldwide. These evidence‐based guidelines have been produced after a systematic review of published studies on infection prevention and control interventions aimed at reducing the transmission of MDR‐GNB.
These guidelines provide advice on screening (testing), treatment and precautions needed to prevent the spread of multidrug‐resistant (MDR) Gram-negative bacteria. They relate to MDR Gram-negative bacteria and have been derived from current peer-reviewed publications and expert opinion. Each recommendation is associated with a class of supporting evidence.
This is a systematic review that looks at the evidence for decolonisation of multidrug-resistant Gram negative bacteria carriers. The aim of these guidelines is to provide recommendations for decolonising regimens targeting multidrug-resistant Gram-negative bacteria (MDR-GNB) carriers in all settings.
Systematic reviews for the prevention and control of carbapenemase-producing Enterobacteriaceae , Acinetobacter baumannii and Pseudomonas aeruginosa
The aim of this project was to review the international literature to describe CPE outbreaks in acute hospital settings globally and identify the control measures used during these outbreaks and report their effectiveness.
A systematic review and re-analysis to assess infection prevention and control interventions on carbapenem-resistant Enterobacteriaceae (CRE) carbapenem-resistant Acinetobacter baumannii (CRAB) and carbapenem-resistant Pseudomonas aeruginosa (CRPsA) in inpatient healthcare facilities to inform World Health Organisation guidelines.
Systematic review of the effectiveness of infection control measures to prevent the transmission of extended-spectrum beta-lactamase-producing Enterobacteriaceae through cross-border transfer of patients.
Healthcare associated infection outbreaks from water reservoirs
This review article looks at healthcare-associated outbreaks and infections associated with a water reservoir. It provides infection prevention strategies and control measures based on the published scientific evidence and available guidelines.
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What is a systematic review?
A systematic review is a method whereby multiple sources of published evidence about a particular clinical issue are reviewed and synthesised in a way that limits bias and presents the combined evidence from all of the sources. Systematic reviews are valuable because they present the summary of the evidence from multiple studies. They may also include a meta-analysis which uses statistical techniques to combine the data provided in several studies into a single estimate.